Description

(+)-2-Amino-2-Phenylbutyric Acid Methyl Ester is a chiral, non-proteinogenic amino acid derivative of significant synthetic utility. This compound matters as a versatile chiral building block and intermediate for the synthesis of pharmaceuticals and fine chemicals, enabling the introduction of a stereocenter with a phenyl substituent. It is primarily needed by research and development chemists in the pharmaceutical industry for creating active pharmaceutical ingredients (APIs), as well as by manufacturers of advanced agrochemicals and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the development of chiral pesticides and herbicides, where stereochemistry is critical for efficacy and environmental safety.
• Peptidomimetics Research: Serves as a constrained amino acid analog in the design of peptide-like molecules with enhanced stability and biological activity.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in asymmetric synthesis to induce enantioselectivity.
• Fine Chemical Production: Acts as a building block for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(+)-2-Amino-2-Phenylbutyric Acid Methyl Ester
CAS No.	52165-71-6
Molecular Formula	C11H15NO2
Molecular Weight	193.24 g/mol
Synonyms	(2R)-2-Amino-2-phenylbutanoic acid methyl ester; Methyl (R)-2-amino-2-phenylbutyrate; (R)-2-Amino-2-phenylbutyric acid methyl ester; L-2-Amino-2-phenylbutyric acid methyl ester; (+)-Methyl 2-amino-2-phenylbutanoate; Methyl α-amino-α-phenylbutyrate; (R)-Methyl 2-amino-2-phenylbutyrate; 2-Phenyl-2-aminobutyric acid methyl ester
EINECS	Contact for details

Quality Control

Our (+)-2-Amino-2-Phenylbutyric Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.