Description

4-Bromobutyldimethylchlorosilane is a versatile bifunctional organosilicon reagent featuring both a reactive chlorosilyl group and a bromoalkyl chain. This compound matters as a critical building block in organic synthesis, enabling the introduction of silyl protecting groups and facilitating subsequent carbon-carbon bond formation. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent in the preparation of active pharmaceutical ingredients (APIs), particularly for introducing silicon-containing moieties or as a linker in prodrug design.
• Agrochemical Production: Serves as a building block for creating novel silicon-based pesticides, herbicides, and plant growth regulators.
• Polymer & Material Science: Employed in the synthesis of functionalized siloxane polymers, silicone resins, and surface-modifying agents to impart specific properties like hydrophobicity or reactivity.
• Surface Derivatization: Utilized for modifying the surface of silica, glass, or other oxides to create alkylbromide-functionalized surfaces for further chemical grafting.
• Cross-Coupling Reactions: The bromobutyl group can participate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) after silylation, enabling complex molecule assembly.
• Protecting Group Chemistry: The chlorosilyl group is effective for protecting hydroxyl groups in multi-step synthetic sequences, with the bromo handle allowing for orthogonal deprotection or further elongation.

Basic Information

Product Name	4-Bromobutyldimethylchlorosilane
CAS No.	52112-26-2
Molecular Formula	C6H14BrClSi
Molecular Weight	229.62 g/mol
Synonyms	4-Bromobutyl(dimethyl)chlorosilane; (4-Bromobutyl)dimethylchlorosilane; Dimethyl(4-bromobutyl)chlorosilane; Chloro(4-bromobutyl)dimethylsilane; 4-Bromobutyldimethylsilyl chloride; Silane, chlorodimethyl(4-bromobutyl)-; 52112-26-2; (4-Bromobutyl)dimethylsilyl chloride
EINECS	Contact for details

Quality Control

Our 4-Bromobutyldimethylchlorosilane undergoes rigorous quality testing to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including GC, NMR, and Karl Fischer titration to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) are available upon request and document compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept under an inert atmosphere (argon or nitrogen) and opened only in a dry, controlled environment. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.