Description

(S)-(-)-α-Hydroxy-γ-Butyrolactone is a high-value chiral building block and intermediate of significant importance in asymmetric synthesis. This optically active lactone derivative is prized for its ability to impart stereochemical control in the production of complex molecules. It is essential for research and manufacturing in the pharmaceutical and fine chemical industries, where it serves as a precursor for active pharmaceutical ingredients (APIs) and other specialty compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of various APIs, including antiviral and cardiovascular drugs.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to construct complex molecular architectures.
• Natural Product Synthesis: Employed in the laboratory synthesis of natural products and bioactive molecules.
• Flavor & Fragrance Industry: Serves as a precursor for certain chiral flavoring agents and aroma chemicals.
• Agrochemical Research: Utilized in the development of chiral pesticides and herbicides.
• Material Science: Investigated as a monomer or modifier for producing specialized polymers.

Basic Information

Product Name	(S)-(-)-α-Hydroxy-γ-Butyrolactone
CAS No.	52079-23-9
Molecular Formula	C₄H₆O₃
Molecular Weight	102.09 g/mol
Synonyms	(S)-(-)-α-Hydroxy-γ-butyrolactone; (S)-3-Hydroxydihydrofuran-2(3H)-one; (S)-3-Hydroxybutyrolactone; (S)-HGBL; L-(-)-α-Hydroxy-γ-butyrolactone; (S)-(-)-3-Hydroxy-γ-butyrolactone; (3S)-3-Hydroxyoxolan-2-one; (S)-(-)-3-Hydroxytetrahydro-2-furanone
EINECS	Contact for details

Quality Control

Our (S)-(-)-α-Hydroxy-γ-Butyrolactone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific rotation are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]²⁰D	-30° to -35° (c=1 in H₂O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.