Description

1,3,5(10)-Estratrien-3,11-Alpha, 17-β-Triol 11-Hemisuccinate CAS NO 52057-95-1 is a high-purity, synthetic steroid derivative, specifically an 11-hemisuccinate ester of a trihydroxy estratriene. This compound is a critical advanced intermediate in the pharmaceutical synthesis of complex steroid-based active pharmaceutical ingredients (APIs). It is essential for research and development laboratories and production facilities requiring precise, high-quality building blocks for creating targeted therapeutic agents. The compound's defined structure enables controlled modifications for developing novel steroid derivatives with specific biological activities.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid hormones and related APIs.
• Research & Development: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new steroid-based drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Research: Utilized in studies investigating steroid metabolism, receptor binding, and enzymatic pathways.
• Process Development: Employed in scaling up and optimizing synthetic routes for steroid manufacturing in a GMP environment.

Basic Information

Product Name	1,3,5(10)-Estratrien-3,11-Alpha, 17-β-Triol 11-Hemisuccinate
CAS No.	52057-95-1
Molecular Formula	C23H30O6
Molecular Weight	402.48 g/mol
Synonyms	11-Hemisuccinyl Estradiol; 11β-Hemisuccinyl Estradiol; 11β-Hydroxyestradiol 11-Hemisuccinate; 3,11α,17β-Trihydroxyestra-1,3,5(10)-trien-11-yl Hydrogen Succinate; Estra-1,3,5(10)-triene-3,11α,17β-triol 11-hemisuccinate; 11-HSE2; 11-Hemisuccinyl-E2
EINECS	Contact for details

Quality Control

Our 1,3,5(10)-Estratrien-3,11-Alpha, 17-β-Triol 11-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets exacting standards for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.