Description

Methyl Trimethylsilyl Malonate is a versatile organosilicon reagent primarily used as a key building block in organic synthesis. This compound matters for its ability to introduce protected malonate ester functionalities, enabling complex molecular construction with high efficiency and selectivity. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for developing active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in the synthesis of complex carboxylic acids, ketones, and heterocyclic compounds.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where the malonate moiety is a key structural element.
• Peptide Mimetics & Prodrug Development: Serves as a protected dicarbonyl equivalent for constructing peptide backbones and designing prodrugs with enhanced bioavailability.
• Material Science Precursor: Employed in the synthesis of specialty polymers, ligands for catalysis, and organic frameworks due to its reactive silyl and ester groups.
• Asymmetric Synthesis: Acts as a substrate or reagent in stereoselective reactions, including Michael additions and alkylations, to create chiral centers.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed and other metal-mediated coupling reactions to form carbon-carbon bonds.

Basic Information

Product Name	Methyl Trimethylsilyl Malonate
CAS No.	51849-23-1
Molecular Formula	C9H18O4Si
Molecular Weight	218.32 g/mol
Synonyms	Methyl (Trimethylsilyl)malonate; Dimethyl (Trimethylsilyl)malonate; Trimethylsilyl Methyl Malonate; Malonic Acid Methyl Trimethylsilyl Ester; Methyl 2-(Trimethylsilyl)malonate; NSC 163082; Methyl (Trimethylsilyl)propanedioate
EINECS	Contact for details

Quality Control

Our Methyl Trimethylsilyl Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.