Description

Mefloquine Hydrochloride is a synthetic quinoline methanol derivative, recognized as a critical active pharmaceutical ingredient (API) in the global fight against malaria. Its primary value lies in its potent activity against chloroquine-resistant strains of *Plasmodium falciparum*, making it a cornerstone for prophylactic and therapeutic regimens. This high-purity compound is essential for pharmaceutical manufacturers, research institutions, and global health organizations developing and producing antimalarial medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of antimalarial tablets and capsules.
• Malaria Prophylaxis: Manufacture of preventative medications for travelers and individuals in endemic regions.
• Malaria Treatment: Production of therapeutic drugs for acute and severe malaria cases, particularly those resistant to other therapies.
• Research & Development: Biochemical and pharmacological studies on malaria parasites and drug resistance mechanisms.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method validation in laboratories.
• Veterinary Medicine: Potential application in veterinary parasitology for related protozoal infections.

Basic Information

Product Name	Mefloquine Hydrochloride
CAS No.	51773-92-3
Molecular Formula	C17H16F6N2O • HCl
Molecular Weight	414.77 g/mol (for free base: 378.31)
Synonyms	Mefloquine HCl; Lariam® (brand name); WR 142,490; (R*,S*)-(±)-erythro-α-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride; (±)-erythro-Mefloquine hydrochloride; Mephaquin; Mefloquine monohydrochloride
EINECS	257-404-1

Quality Control

Our Mefloquine Hydrochloride is manufactured under strict quality management systems. It is typically supplied to meet pharmaceutical-grade standards, with specifications aligned with major pharmacopoeias. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, ensuring traceability and compliance for regulatory submissions (e.g., FDA, EMA).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Optical Rotation	Specific range provided per grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.