Description

4-Chloropyridine-2-Carbonyl Chloride Hydrochloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound matters for its role as a key building block in the creation of complex molecules, particularly in pharmaceutical and agrochemical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing pyridine-based active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing a functionalized pyridine core for various therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the chloropyridine moiety imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the development of functional organic materials, such as metal-organic frameworks (MOFs) and organic semiconductors.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic and Industrial R&D: Fundamental building block in research laboratories for exploring new chemical reactions and developing novel compound libraries.

Basic Information

Product Name	4-Chloropyridine-2-Carbonyl Chloride Hydrochloride
CAS No.	51727-15-2
Molecular Formula	C6H4Cl2NO·HCl
Molecular Weight	212.46 g/mol (Free base: 175.99 g/mol)
Synonyms	2-(Chlorocarbonyl)-4-chloropyridine hydrochloride; 4-Chloropicolinoyl chloride hydrochloride; 4-Chloro-2-pyridinecarbonyl chloride hydrochloride; Picolinoyl chloride, 4-chloro-, hydrochloride; 4-Chloro-2-pyridylcarbonyl chloride hydrochloride; 4-Chloropyridine-2-carboxylic acid chloride hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Chloropyridine-2-Carbonyl Chloride Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality management system is designed to meet the stringent requirements of research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.