Description

2-Methoxy-3,16α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene is a highly functionalized, silyl-protected derivative of estradiol, designed for advanced synthetic chemistry applications. This compound is critical for researchers and manufacturers requiring precise, stable intermediates in the synthesis of complex steroid analogs and pharmaceutical active ingredients. It is primarily utilized by the pharmaceutical, biotechnology, and advanced fine chemical sectors for process development and high-value target molecule synthesis.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of novel steroid-based therapeutics and hormone analogs.
• Process Chemistry: Used in research and development (R&D) and scale-up for creating complex molecular architectures with high stereochemical control.
• Biochemical Research: Serves as a precursor in studies investigating steroid receptor interactions and metabolic pathways.
• Fine Chemical Synthesis: Employed in the production of specialized, high-purity compounds for academic and industrial research.
• Reference Standard: Can be utilized as a chromatographic standard for analytical method development and quality control in steroid manufacturing.

Basic Information

Product Name	2-Methoxy-3,16α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene
CAS No.	51497-48-4
Molecular Formula	C31H54O4Si3
Molecular Weight	575.0 g/mol (approx.)
Synonyms	2-Methoxy-3,16α,17β-tris(trimethylsilyloxy)estra-1,3,5(10)-triene; 3,16α,17β-Tris-O-(trimethylsilyl)-2-methoxyestra-1,3,5(10)-triene; Estra-1,3,5(10)-triene-2-methoxy-3,16α,17β-triol, tris(trimethylsilyl) ether; 2-Methoxyestradiol-3,16,17-tris(trimethylsilyl) ether; Silylated 2-Methoxyestradiol Derivative; TMS-protected 2-MeOE2
EINECS	Contact for details

Quality Control

Our 2-Methoxy-3,16α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development use. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.