Description

4,17β-Bis[(Trimethylsilyl)Oxy]-3-Methoxyestra-1,3,5(10)-Triene CAS NO 51497-45-1 is a high-purity, protected steroid derivative, specifically a trimethylsilyl (TMS) ether of a methoxyestratriene. This compound serves as a critical advanced intermediate in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development and production of steroidal drugs and reference standards.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroidal hormones and therapeutic agents.
• Research Chemical: Used in academic and industrial research for studying steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Development: Employed in optimizing synthetic routes for the scalable production of target steroid molecules.
• Fine Chemical Synthesis: Utilized in the preparation of specialized steroidal compounds for various life science applications.

Basic Information

Product Name	4,17β-Bis[(Trimethylsilyl)Oxy]-3-Methoxyestra-1,3,5(10)-Triene
CAS No.	51497-45-1
Molecular Formula	C25H42O3Si2
Molecular Weight	446.78 g/mol
Synonyms	3-Methoxyestra-1,3,5(10)-triene-4,17β-diol bis(trimethylsilyl) ether; 3-Methoxyestra-1,3,5(10)-triene-4,17β-diol 4,17-bis(trimethylsilyl) ether; 4,17β-Bis(trimethylsiloxy)-3-methoxyestra-1,3,5(10)-triene; 3-Methoxyestra-1,3,5(10)-triene-4,17β-diol bis(TMS) ether; 4,17β-Di-O-trimethylsilyl-3-methoxyestra-1,3,5(10)-triene
EINECS	Contact for details

Quality Control

Our 4,17β-Bis[(Trimethylsilyl)Oxy]-3-Methoxyestra-1,3,5(10)-Triene is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency suitable for research and synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.