Description

3,4-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-17-One is a high-purity, protected steroid derivative, specifically a 3,4-bis-O-trimethylsilyl ether of estrone. This compound is a critical synthetic intermediate, valued for its role in introducing protective groups that enable selective chemical transformations in complex organic synthesis. It is primarily utilized by research institutions and pharmaceutical development companies engaged in the synthesis of novel steroid-based therapeutics and advanced chemical probes.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and hormone analogs.
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies involving protected phenol functionalities.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in steroid chemistry.
• Chemical Biology: Employed in the preparation of labeled or modified steroid probes for studying receptor interactions and metabolic pathways.

Basic Information

Product Name	3,4-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-17-One
CAS No.	51497-39-3
Molecular Formula	C24H40O3Si2
Molecular Weight	432.75 g/mol
Synonyms	Estrone 3,4-Bis(trimethylsilyl) Ether; 17-Oxoestra-1,3,5(10)-triene-3,4-diyl Bis(trimethylsilyl) Ether; 3,4-Bis-O-(trimethylsilyl)estrone; 3,4-Bis(trimethylsilyloxy)estra-1,3,5(10)-trien-17-one; Estrone 3,4-bis(TMS) ether; NSC 338950
EINECS	Contact for details

Quality Control

Our 3,4-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-17-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.