Description

2,3-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One is a key organosilicon-protected derivative of a steroidal ketone, serving as a critical advanced intermediate in complex organic synthesis. Its primary value lies in enabling precise chemical transformations while protecting sensitive functional groups, ensuring high-yield, high-purity outcomes in demanding processes. This compound is essential for research and development chemists and production units in the pharmaceutical and fine chemical industries, particularly for the synthesis of novel steroid-based active pharmaceutical ingredients (APIs) and other high-value specialty molecules.

Application

• Pharmaceutical Intermediate: A pivotal building block for the synthesis of steroidal drugs and hormone analogs.
• Organic Synthesis Reagent: Used in multi-step synthesis to protect hydroxyl groups and direct regioselective reactions.
• Research & Development: Employed in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities.
• Fine Chemical Production: Integral to the manufacture of complex, high-purity specialty chemicals for various advanced applications.

Basic Information

Product Name	2,3-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One
CAS No.	51497-38-2
Molecular Formula	C24H42O3Si2
Molecular Weight	434.77 g/mol
Synonyms	2,3-Bis(trimethylsilyloxy)estra-1,3,5(10)-trien-17-one; 17-Oxo-1,3,5(10)-estratriene-2,3-diyl bis(trimethylsilyl) ether; 2,3-Bis-O-(trimethylsilyl)estrone; Estrone 2,3-bis(trimethylsilyl) ether; Estrone 2,3-bis-O-TMS ether; 51497-38-2; 1,3,5(10)-Estratrien-17-one, 2,3-bis[(trimethylsilyl)oxy]-
EINECS	Contact for details

Quality Control

Our 2,3-Bis(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, purity, and impurity profiles. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.