Description

5'-o-(Trimethylsilyl)Uridine is a key protected nucleoside derivative, specifically a silyl ether of uridine. This compound is essential for synthetic organic and medicinal chemists as a versatile building block in oligonucleotide synthesis and carbohydrate chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for the development of novel therapeutics and diagnostic probes.

Application

• Oligonucleotide Synthesis: Acts as a crucial intermediate for the protection of the 5'-hydroxyl group during the solid-phase or solution-phase synthesis of RNA and modified oligonucleotides.
• Pharmaceutical Intermediates: Serves as a building block in the research and development of nucleoside-based antiviral and anticancer drugs.
• Carbohydrate Chemistry: Used in the synthesis of complex nucleoside analogs and modified sugars where selective protection is required.
• Bioconjugation: Facilitates the site-specific modification of nucleosides for creating labeled probes used in diagnostics and biochemical assays.
• Academic & Industrial R&D: Employed in research laboratories for studying nucleic acid structure, function, and for developing new synthetic methodologies.
• Scale-up Production: Supplied in quantities suitable for process development and pilot-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5'-o-(Trimethylsilyl)Uridine
CAS No.	51432-36-1
Molecular Formula	C12H20N2O6Si
Molecular Weight	316.39 g/mol
Synonyms	Uridine, 5'-O-(trimethylsilyl)-; 5'-O-Trimethylsilyluridine; 5'-TMS-Uridine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-((trimethylsilyl)oxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5'-O-(TMS)Uridine; 2',3'-O-Isopropylidene-5'-O-(trimethylsilyl)uridine (related protected form); TMS-Urd
EINECS	Contact for details

Quality Control

Our 5'-o-(Trimethylsilyl)Uridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., DMSO, DMF, acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.