Description

(10Bs)-1,2,3,3Aβ,6,7,8,9,10,10Aα,13,13Aβ-Dodecahydro-6α-Acetoxy-1,1-Dimethyl-7-Methylene-5H-10β,13β-Epoxy-5Aβ,8β-Methanocyclohepta[C]Furo[3,4-E][1]Benzopyran-5-One is a complex diterpenoid derivative, specifically a functionalized parthenolide analog, valued for its role as a key synthetic intermediate in advanced organic chemistry. Its intricate polycyclic structure makes it a critical building block for pharmaceutical research, particularly in the development of novel anti-inflammatory and anticancer agents. This high-purity compound is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel therapeutic compounds, especially those targeting inflammation and oncology pathways.
• Medicinal Chemistry Research: Used as a scaffold or starting material for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Biochemical Probe Development: Employed in the creation of specialized probes to study biological mechanisms related to sesquiterpene lactone activity.
• Fine Chemical Synthesis: A valuable intermediate for the production of other complex, high-value diterpenoids and natural product analogs.
• Academic Research: Utilized in university and institutional labs for methodological development in total synthesis and stereoselective transformations.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in related compound analysis.

Basic Information

Item	Details
Product Name	(10Bs)-1,2,3,3Aβ,6,7,8,9,10,10Aα,13,13Aβ-Dodecahydro-6α-Acetoxy-1,1-Dimethyl-7-Methylene-5H-10β,13β-Epoxy-5Aβ,8β-Methanocyclohepta[C]Furo[3,4-E][1]Benzopyran-5-One
CAS No.	51419-50-2
Molecular Formula	C22H28O6
Molecular Weight	388.46 g/mol
Synonyms	6α-Acetoxyparthenolide; 6α-Acetoxy-1,1-dimethyl-7-methylene-5H-10β,13β-epoxy-5α,8β-methanocyclohepta[c]furo[3,4-e][1]benzopyran-5-one; Parthenolide 6-acetate; 6-Acetylparthenolide; (10Bs)-Dodecahydro-6α-acetoxy-1,1-dimethyl-7-methylene-5H-10β,13β-epoxy-5α,8β-methanocyclohepta[c]furo[3,4-e][1]benzopyran-5-one; NSC 106579; A derivative of parthenolide.
EINECS	Contact for details

Quality Control

Our (10Bs)-1,2,3,3Aβ,6,7,8,9,10,10Aα,13,13Aβ-Dodecahydro-6α-Acetoxy-1,1-Dimethyl-7-Methylene-5H-10β,13β-Epoxy-5Aβ,8β-Methanocyclohepta[C]Furo[3,4-E][1]Benzopyran-5-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. Production adheres to cGMP guidelines where applicable. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to prevent degradation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay	≥ 97.0% (by HPLC normalization)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.