Description

(E)-Ethyl 4-Bromo-3-Methyl-2-Butenoate is a high-purity, versatile α,β-unsaturated ester building block featuring a bromine substituent, making it a valuable intermediate for advanced organic synthesis. Its core value lies in enabling precise molecular construction through cross-coupling reactions and nucleophilic substitutions, which are fundamental to modern pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex molecules via Suzuki, Stille, or Negishi cross-coupling reactions, enabling the synthesis of potential drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the reactive bromine and ester functionalities for structural diversification.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialized polymers and liquid crystals with tailored electronic or optical properties.
• Organic Synthesis Building Block: Employed in Michael additions, alkylations, and other C-C bond-forming reactions to create complex, branched organic frameworks in academic and industrial laboratories.
• Flavor & Fragrance Ingredient Precursor: Utilized in the multi-step synthesis of specific ester-based aroma compounds.

Basic Information

Product Name	(E)-Ethyl 4-Bromo-3-Methyl-2-Butenoate
CAS No.	51371-55-2
Molecular Formula	C7H11BrO2
Molecular Weight	207.07 g/mol
Synonyms	Ethyl (E)-4-Bromo-3-methylbut-2-enoate; 4-Bromo-3-methyl-2-butenoic Acid Ethyl Ester; 2-Butenoic acid, 4-bromo-3-methyl-, ethyl ester, (E)-; Ethyl 4-bromo-3-methylcrotonate; (E)-Ethyl 4-bromo-3-methylbut-2-enoate; 4-Bromo-3-methylcrotonic acid ethyl ester
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 4-Bromo-3-Methyl-2-Butenoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (GC/HPLC)	≥ 95.0% (E)-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.