Description

(E)-Ethyl 4-Bromo-3-Methyl-2-Butenoate is a high-purity, versatile α,β-unsaturated ester building block, essential for advanced organic synthesis. Its core value lies in the strategic placement of bromine and methyl groups on the alkene framework, enabling precise carbon-carbon bond formation and functional group transformations. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated olefin motifs.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides that leverage its reactive bromo-alkene functionality.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed reactions like Heck, Suzuki, and Sonogashira couplings to introduce complex side chains.
• Material Science Research: Used in the development of specialty monomers for polymers with tailored properties, such as liquid crystals or functional coatings.
• Organic Synthesis Reagent: Employed in Michael additions, Diels-Alder reactions, and nucleophilic substitution reactions due to its activated double bond and leaving group.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or inhibitors for studying biological pathways and enzyme mechanisms.

Basic Information

Product Name	(E)-Ethyl 4-Bromo-3-Methyl-2-Butenoate
CAS No.	51318-62-8
Molecular Formula	C7H11BrO2
Molecular Weight	207.07 g/mol
Synonyms	Ethyl (E)-4-Bromo-3-methylbut-2-enoate; 4-Bromo-3-methyl-2-butenoic Acid Ethyl Ester; (E)-Ethyl 4-Bromo-3-methylcrotonate; 2-Butenoic acid, 4-bromo-3-methyl-, ethyl ester, (E)-; Ethyl trans-4-bromo-3-methyl-2-butenoate; 4-Bromo-3-methyl-trans-crotonic acid ethyl ester; Ethyl 4-bromo-3-methyl-(E)-2-butenoate
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 4-Bromo-3-Methyl-2-Butenoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity ((E)-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.