Description

Norethindrone-4 Beta,5 β-Epoxide is a key synthetic intermediate and a derivative of the progestin norethindrone. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel steroid-based therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of hormonal agents and other specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced steroid hormones and progestin derivatives.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of new chemical entities (NCEs) targeting hormone receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis (HPLC, GC-MS).
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex steroid molecules.
• Academic Research: Utilized in university and institutional labs for studying steroid metabolism, epoxide reactivity, and organic synthesis methodologies.

Basic Information

Product Name	Norethindrone-4 Beta,5 β-Epoxide
CAS No.	51267-63-1
Molecular Formula	C₂₀H₂₆O₃
Molecular Weight	314.42 g/mol
Synonyms	19-Norpregn-4-en-20-yn-3-one, 4β,5β-epoxy-17-hydroxy-, (17α)-; 4β,5β-Epoxynorethindrone; 17α-Ethynyl-4β,5β-epoxy-19-nortestosterone; 4β,5β-Epoxy-17α-ethynyl-19-nortestosterone; 4β,5β-Epoxy-19-nor-17α-pregn-4-en-20-yn-3-one; Norethisterone 4β,5β-epoxide
EINECS	Contact for details

Quality Control

Our Norethindrone-4 Beta,5 β-Epoxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and research chemicals. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.