Description

Piperidine, 4-(Trimethylsilyl)- (9Ci) is a specialized organosilicon derivative of piperidine, serving as a valuable building block in advanced organic synthesis. This compound is particularly significant for introducing the trimethylsilyl-protected 4-aminopiperidine moiety, a key structural feature in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas requiring functionalized piperidine scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the silylated piperidine structure can modulate biological activity and physicochemical properties.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other advanced materials where silicon incorporation alters electronic and bulk properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring protected amine functionalities for multi-step synthetic routes.

Basic Information

Product Name	Piperidine, 4-(Trimethylsilyl)- (9Ci)
CAS No.	51243-68-6
Molecular Formula	C8H19NSi
Molecular Weight	157.33 g/mol
Synonyms	4-(Trimethylsilyl)piperidine; 4-Trimethylsilylpiperidine; 1-(Trimethylsilyl)-4-piperidine; 4-Piperidinyltrimethylsilane; N-Trimethylsilyl-4-piperidinamine; 4-TMS-piperidine; 4-Trimethylsilyl-1-piperidine; Piperidine, 4-(trimethylsilyl)-
EINECS	Contact for details

Quality Control

Every batch of Piperidine, 4-(Trimethylsilyl)- is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to meet the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.