Description

R(+)-Thioamylal Sodium is the sodium salt of the R-enantiomer of thioamylal, a thiobarbiturate derivative. This high-purity chiral compound is critical for pharmaceutical research and development, particularly in the study of stereoselective drug action and metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, anesthesiology, and the development of new central nervous system (CNS) agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in drug manufacturing.
• Neuroscience Research: Used as a tool compound in preclinical studies to investigate the mechanisms of barbiturate action, GABA receptor modulation, and stereospecific pharmacokinetics.
• Metabolic Pathway Studies: Employed in research to understand the enantioselective metabolism and clearance of thiobarbiturates.
• Anesthetic Pharmacology: Applied in comparative studies of anesthetic agents to explore the relationship between chemical structure, chirality, and pharmacological activity.
• Process Chemistry & Intermediate: Can be used as a chiral intermediate or starting material in the synthesis of more complex, targeted therapeutic molecules.

Basic Information

Product Name	R(+)-Thioamylal Sodium
CAS No.	51165-40-3
Molecular Formula	C11H17N2NaO2S
Molecular Weight	264.32 g/mol
Synonyms	5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid sodium salt (R-enantiomer); (R)-Thioamylal Sodium; Sodium (R)-5-ethyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; R-(+)-Thioamylal Sodium; (+)-Thioamylal Sodium; Thioseconal Sodium (R-enantiomer); BAYTINAL (R-enantiomer); 5-Ethyl-5-(1-methylbutyl)-2-thiobarbiturate sodium salt
EINECS	Contact for details

Quality Control

Our R(+)-Thioamylal Sodium is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications suitable for research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.