Description

S(-)-Secobarbital Sodium is the sodium salt of the S-enantiomer of secobarbital, a short-acting barbiturate derivative. This specific enantiomer is of significant interest in pharmaceutical research and development due to its distinct pharmacological profile compared to its racemic mixture. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in neuroscience, pharmacokinetic studies, and the development of chiral drug substances. The compound is supplied with a high level of purity to meet the stringent demands of advanced research applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and assay development in drug manufacturing.
• Chiral Pharmacology Research: Critical for studying the stereoselective metabolism, receptor binding, and efficacy of barbiturate enantiomers.
• Analytical Method Development: Serves as a high-purity standard for calibrating HPLC, GC, and LC-MS systems in forensic and clinical toxicology labs.
• Neuroscience Studies: Employed in preclinical research to investigate mechanisms of sedation, hypnosis, and GABAA receptor modulation.
• Impurity Profiling: Used to identify and quantify enantiomeric impurities in bulk secobarbital sodium or related pharmaceutical formulations.

Basic Information

Product Name	S(-)-Secobarbital Sodium
CAS No.	51165-37-8
Molecular Formula	C12H17N2NaO3
Molecular Weight	260.27 g/mol
Synonyms	(S)-Secobarbital Sodium; (-)-Secobarbital Sodium; S-5-Allyl-5-(1-methylbutyl)barbituric acid sodium salt; L-Secobarbital Sodium; Quinalbarbitone Sodium (S-enantiomer); Secobarbital Sodium Enantiomer; Seconal Sodium (S-form)
EINECS	Contact for details

Quality Control

Every batch of S(-)-Secobarbital Sodium is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to support its use as a research chemical, including chiral purity verification. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting parameters such as assay, enantiomeric excess, and identification. Our quality systems are designed to ensure consistency, traceability, and reliability for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.