Description

Megestrol Acetate CAS NO 51154-23-5 is a synthetic, steroidal progestin widely recognized for its potent hormonal activity. This compound is of critical importance in the pharmaceutical industry for the development of therapeutic agents targeting hormone-dependent conditions. It is primarily required by manufacturers of active pharmaceutical ingredients (APIs), research institutions, and formulation scientists working in oncology and endocrinology.

Application

• Pharmaceutical API: Primary use as the active ingredient in medications for the palliative treatment of advanced breast and endometrial cancer.
• Appetite Stimulant: Formulation component in therapies for cachexia (wasting syndrome) associated with cancer and AIDS.
• Hormone Replacement Therapy (HRT): Used in combination with estrogens for menopausal symptom management.
• Contraceptive Formulations: A key progestogen component in certain oral contraceptive pills.
• Veterinary Medicine: Application in animal health for estrus synchronization and the treatment of hormonal disorders.
• Biochemical Research: A standard compound for studying progesterone receptor interactions and steroid hormone pathways in laboratory settings.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical manufacturing.

Basic Information

Product Name	Megestrol Acetate
CAS No.	51154-23-5
Molecular Formula	C24H32O4
Molecular Weight	384.51 g/mol
Synonyms	Megestrol Acetate; 17α-Acetoxy-6-methylpregna-4,6-diene-3,20-dione; 6-Methyl-6-dehydro-17α-acetoxyprogesterone; BDH 1298; NSC-71423; Maygace; Megace; Pallace
EINECS	257-104-6

Quality Control

Our Megestrol Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided with every shipment, detailing compliance with in-house specifications aligned with major pharmacopoeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.