Description

n-(2-Pyridylmethyl)Trifluoromethanesulfonamide is a specialized organofluorine building block featuring a reactive sulfonamide group. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working in medicinal chemistry, where it is used to introduce the trifluoromethanesulfonamide moiety, a group known to influence the metabolic stability and binding affinity of target compounds. Its precise structure makes it an essential reagent for constructing nitrogen-containing heterocycles with tailored properties.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand Synthesis: Serves as a precursor for constructing complex ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and fine chemical manufacturers engaged in bespoke synthesis projects.
• Academic Research: Utilized in university laboratories for methodological development in organic synthesis and fluorine chemistry.

Basic Information

Product Name	n-(2-Pyridylmethyl)Trifluoromethanesulfonamide
CAS No.	51061-76-8
Molecular Formula	C7H7F3N2O2S
Molecular Weight	240.21 g/mol
Synonyms	N-[(Pyridin-2-yl)methyl]-1,1,1-trifluoromethanesulfonamide; 2-Pyridinemethanesulfonamide, N-(trifluoromethyl)-; Trifluoromethanesulfonamide, N-(2-pyridinylmethyl)-; N-(Pyridin-2-ylmethyl)trifluoromethanesulfonamide; N-(2-Pyridylmethyl)trifluoromethanesulphonamide; 2-(Trifluoromethylsulfonamidomethyl)pyridine; N-(Pyridin-2-ylmethyl)-1,1,1-trifluoromethanesulfonamide
EINECS	Contact for details

Quality Control

Our n-(2-Pyridylmethyl)Trifluoromethanesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support cGMP-compliant documentation for advanced pharmaceutical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.