Description

Mizoribine CAS NO 50924-49-7 is a synthetic nucleoside analog with potent immunosuppressive activity. This compound is valued for its selective inhibition of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the *de novo* pathway of guanine nucleotide synthesis. It is primarily utilized in pharmaceutical research and development for applications in immunology and transplant medicine.

Application

• Immunosuppressive Drug Intermediate: A key active pharmaceutical ingredient (API) in the formulation of immunosuppressant medications.
• Autoimmune Disease Research: Used in preclinical and clinical research for conditions like lupus nephritis and rheumatoid arthritis.
• Organ Transplant Research: Investigated for preventing organ rejection in transplant models.
• Biochemical Research: Serves as a selective IMPDH inhibitor to study lymphocyte proliferation and purine metabolism pathways.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for drug testing and method validation.
• Pharmaceutical Synthesis: Acts as a critical building block in the synthesis of more complex immunosuppressive agents.

Basic Information

Product Name	Mizoribine
CAS No.	50924-49-7
Molecular Formula	C9H13N3O6
Molecular Weight	259.22 g/mol
Synonyms	4-Carbamoyl-1-β-D-ribofuranosylimidazolium-5-olate; Bredinin; MZR; Mycophenolate mizoribine; 1-β-D-Ribofuranosyl-1H-imidazole-4-carboxamide 5-oxide; 4-Carbamoyl-1-β-D-ribofuranosylimidazolium-5-olate; 1H-Imidazole-4-carboxamide, 1-β-D-ribofuranosyl-, 5-oxide
EINECS	Contact for details

Quality Control

Our Mizoribine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.