Description

Boc-Alanine Pentafluorophenyl Ester is a high-purity, activated ester derivative of the amino acid alanine, protected at the N-terminus with a tert-butoxycarbonyl (Boc) group. This compound is a critical reagent in solid-phase peptide synthesis (SPPS), enabling efficient and racemization-free coupling reactions to build complex peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on producing peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential addition of alanine residues in peptide chain assembly.
• Solution-Phase Peptide Synthesis: Used in traditional coupling methodologies for synthesizing shorter peptide sequences or fragments.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the research and production of therapeutic peptides and active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the site-specific labeling or modification of proteins, antibodies, and other biomolecules.
• Proteomics Research: Employed in the synthesis of custom peptides for use as standards, probes, or enzyme substrates.
• Material Science: Used in the synthesis of peptide-based polymers and advanced biomaterials.

Basic Information

Product Name	Boc-Alanine Pentafluorophenyl Ester
CAS No.	50903-48-5
Molecular Formula	C₁₄H₁₄F₅NO₄
Molecular Weight	355.26 g/mol
Synonyms	Boc-Ala-OPfp; Boc-L-Alanine Pentafluorophenyl Ester; N-(tert-Butoxycarbonyl)-L-alanine Pentafluorophenyl Ester; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]propanoic Acid 2,3,4,5,6-Pentafluorophenyl Ester; N-Boc-L-alanine Pentafluorophenyl Ester; N-α-Boc-L-alanine Pentafluorophenyl Ester; Boc-L-Ala-OPfp; Pentafluorophenyl N-(tert-Butoxycarbonyl)-L-alaninate
EINECS	Contact for details

Quality Control

Our Boc-Alanine Pentafluorophenyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.