Description

5,8-Epoxy-5,8-Dihydroretinoic Acid Trimethylsilyl Ester is a chemically modified derivative of retinoic acid, specifically protected as a trimethylsilyl (TMS) ester. This compound is a critical synthetic intermediate and reference standard in the research and development of novel retinoid-based pharmaceuticals and bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on dermatology, oncology, and metabolic disease pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel retinoid analogs and prodrugs for therapeutic applications.
• Reference Standard: Used in analytical method development and quality control (QC/QA) for retinoid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: A tool compound for studying retinoid metabolism, receptor binding (RAR/RXR), and signaling pathways in cell culture and in vitro assays.
• Chemical Synthesis: Serves as a protected intermediate in multi-step organic synthesis, leveraging the TMS group for stability during reactions.
• Dermatological Research: Investigated for potential applications in modulating skin cell proliferation and differentiation.

Basic Information

Product Name	5,8-Epoxy-5,8-Dihydroretinoic Acid Trimethylsilyl Ester
CAS No.	50876-24-9
Molecular Formula	C26H40O3Si
Molecular Weight	428.68 g/mol
Synonyms	5,8-Epoxy-5,8-dihydroretinoic acid TMS ester; Retinoic acid, 5,8-epoxy-5,8-dihydro-, trimethylsilyl ester; Trimethylsilyl 5,8-epoxy-5,8-dihydroretinoate; (all-E)-5,8-Epoxy-5,8-dihydroretinoic Acid Trimethylsilyl Ester; TMS-Epoxyretinoate
EINECS	Contact for details

Quality Control

Our 5,8-Epoxy-5,8-Dihydroretinoic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to orange viscous oil or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Solubility	Soluble in common organic solvents (DMSO, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.