Description

2-Amino-5-Chloro-Nicotinic Acid Methyl Ester is a high-purity, versatile chemical intermediate of significant importance in advanced organic synthesis. Its core value lies in its functionalized pyridine structure, which serves as a critical building block for constructing complex molecules with targeted biological activity. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its chloronicotinate scaffold.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the multi-step synthesis of complex APIs requiring a functionalized aminonicotinate moiety.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions.

Basic Information

Product Name	2-Amino-5-Chloro-Nicotinic Acid Methyl Ester
CAS No.	50735-33-6
Molecular Formula	C7H7ClN2O2
Molecular Weight	186.60 g/mol
Synonyms	Methyl 2-Amino-5-chloronicotinate; 5-Chloro-2-aminonicotinic Acid Methyl Ester; 2-Amino-5-chloro-3-pyridinecarboxylic Acid Methyl Ester; Methyl 5-Chloro-2-aminonicotinate; 5-Chloro-2-aminopyridine-3-carboxylic Acid Methyl Ester; 2-Amino-5-chloropyridine-3-carboxylic Acid Methyl Ester; 50735-33-6; Methyl 2-amino-5-chloropyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Chloro-Nicotinic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.