Description

2-Hydroxy-4-(Trifluoromethyl)Pyridine is a versatile heterocyclic building block characterized by a pyridine core substituted with a hydroxyl group and a trifluoromethyl group. This unique molecular structure makes it a critical intermediate for synthesizing advanced compounds with enhanced properties like metabolic stability and lipophilicity. It is primarily needed by pharmaceutical, agrochemical, and material science R&D teams developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis for organic synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers where fluorine substitution modifies electronic and physical properties.
• Chemical Research & Development: A valuable building block for medicinal chemistry and process chemistry in custom synthesis and scale-up projects.

Basic Information

Product Name	2-Hydroxy-4-(Trifluoromethyl)Pyridine
CAS No.	50650-59-4
Molecular Formula	C6H4F3NO
Molecular Weight	163.10 g/mol
Synonyms	4-(Trifluoromethyl)pyridin-2-ol; 2-Pyridinol, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2-hydroxypyridine; 2-Hydroxy-4-trifluoromethylpyridine; 2-Hydroxy-α,α,α-trifluoro-p-picoline; 4-Trifluoromethyl-2-pyridone; 2(1H)-Pyridinone, 4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-(Trifluoromethyl)Pyridine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing including HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.