Description

4-[1A,2,7,7A-Tetrahydro-2-Methoxy-8-Phenyl-1,2,7-Metheno-1H-Cyclopropa[B]Naphthalen-1-Yl]Pyridine is a complex, polycyclic organic compound featuring a unique bridged structure that combines naphthalene, cyclopropane, and pyridine moieties. This structural complexity makes it a valuable advanced intermediate or building block in sophisticated organic synthesis, particularly for pharmaceuticals and materials science. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or with complex steric requirements.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides where its rigid, three-dimensional structure can impart unique biological activity.
• Ligand and Catalyst Development: The nitrogen-containing pyridine moiety makes it a candidate for developing novel ligands in asymmetric catalysis or metal-organic frameworks (MOFs).
• Material Science Precursor: Acts as a building block for organic electronic materials, such as non-linear optical (NLO) materials or components for organic light-emitting diodes (OLEDs).
• Academic and R&D: Employed in university and institutional research for studying cyclopropane ring reactions, polycyclic compound chemistry, and structure-activity relationships (SAR).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes requiring this specialized scaffold.

Basic Information

Product Name	4-[1A,2,7,7A-Tetrahydro-2-Methoxy-8-Phenyl-1,2,7-Metheno-1H-Cyclopropa[B]Naphthalen-1-Yl]Pyridine
CAS No.	50559-47-2
Molecular Formula	C24H21NO
Molecular Weight	339.43 g/mol
Synonyms	4-(1a,2,7,7a-Tetrahydro-2-methoxy-8-phenyl-1,2,7-metheno-1H-cyclopropa[b]naphthalen-1-yl)pyridine; 1-(4-Pyridinyl)-1a,2,7,7a-tetrahydro-2-methoxy-8-phenyl-1,2,7-metheno-1H-cyclopropa[b]naphthalene; 4-(2-Methoxy-8-phenyl-1,2,7-metheno-1H-cyclopropa[b]naphthalen-1(7aH)-yl)pyridine; 8-Phenyl-2-methoxy-1-(4-pyridyl)-1,2,7-metheno-1H-cyclopropa[b]naphthalene; Light-sensitive cyclopropanaphthalene pyridine derivative. Contact for additional trade names or registry numbers.
EINECS	Contact for details

Quality Control

Our production of 4-[1A,2,7,7A-Tetrahydro-2-Methoxy-8-Phenyl-1,2,7-Metheno-1H-Cyclopropa[B]Naphthalen-1-Yl]Pyridine adheres to stringent internal quality standards to ensure batch-to-batch consistency and purity for research and development applications. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque, and the material should be handled under subdued lighting where practical.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.