Description

1,2,3,4-Tetrahydro-1',3,3-Trimethylspiro[γ-Carboline-1,4'-Piperidine] is a high-purity synthetic organic compound belonging to the spirocyclic alkaloid class, serving as a critical advanced intermediate in modern pharmaceutical research and development. Its complex fused-ring structure makes it a valuable scaffold for creating novel bioactive molecules targeting the central nervous system. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly for projects involving neurological and psychiatric therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those with neurological activity.
• Neurological Research: Used as a core scaffold in medicinal chemistry for developing ligands for serotonin and other neurotransmitter receptors.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying spirocyclic compound chemistry and pharmacology.
• Pre-clinical Development: Integral to the discovery phase for evaluating new therapeutic agents in animal models.

Basic Information

Product Name	1,2,3,4-Tetrahydro-1',3,3-Trimethylspiro[γ-Carboline-1,4'-Piperidine]
CAS No.	50527-41-8
Molecular Formula	C₁₉H₂₆N₄
Molecular Weight	310.44 g/mol
Synonyms	1,2,3,4-Tetrahydro-1',3,3-trimethylspiro[γ-carboline-1,4'-piperidine]; Spiro[γ-carboline-1,4'-piperidine], 1,2,3,4-tetrahydro-1',3,3-trimethyl-; 1',3,3-Trimethylspiro[γ-carboline-1,4'-piperidine]; 1,2,3,4-Tetrahydro-1',3,3-trimethylspiro[γ-carboline-1,4'-piperidine]; 1,2,3,4-Tetrahydro-1',3,3-trimethylspiro[γ-carboline-1,4'-piperidine] (CAS 50527-41-8); 1,2,3,4-Tetrahydro-1',3,3-trimethylspiro[γ-carboline-1,4'-piperidine] (main IUPAC name); 1,2,3,4-Tetrahydro-1',3,3-trimethylspiro[γ-carboline-1,4'-piperidine] (alternate spelling); 1,2,3,4-Tetrahydro-1',3,3-trimethylspiro[γ-carboline-1,4'-piperidine] (common research name)
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-1',3,3-Trimethylspiro[γ-Carboline-1,4'-Piperidine] is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; containers should be kept sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.