Description

Diethyl 2-Acetamido-2-((5-(Phenylmethoxy)Indol-3-Yl)Methyl)Malonate is a high-purity, synthetic organic compound featuring a complex indole-based molecular structure. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of more complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in the fields of oncology and neurology.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a sophisticated building block for constructing indole-containing compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis: Used in the development of novel synthetic methodologies, particularly in reactions involving malonate esters and protected indole derivatives.
• Biochemical Research: Employed in the study of enzyme inhibitors and receptor ligands due to its specific molecular architecture.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	Diethyl 2-Acetamido-2-((5-(Phenylmethoxy)Indol-3-Yl)Methyl)Malonate
CAS No.	50469-23-3
Molecular Formula	C25H28N2O5
Molecular Weight	436.50 g/mol
Synonyms	Diethyl (2-Acetamido-2-((5-(benzyloxy)-1H-indol-3-yl)methyl)propanedioate); 2-Acetamido-2-((5-(benzyloxy)-1H-indol-3-yl)methyl)malonic Acid Diethyl Ester; Diethyl 2-Acetamido-2-[(5-benzyloxy-1H-indol-3-yl)methyl]malonate; Propanedioic acid, 2-acetamido-2-[[5-(phenylmethoxy)-1H-indol-3-yl]methyl]-, 1,3-diethyl ester; 50469-23-3; CAS 50469-23-3
EINECS	Contact for details

Quality Control

Our Diethyl 2-Acetamido-2-((5-(Phenylmethoxy)Indol-3-Yl)Methyl)Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical-grade intermediates. Certificates of Analysis (COA) detailing results from HPLC, NMR, and other relevant tests are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.