Description

6-[Bis(2-Chloroethyl)Amino]-m-Toluic Acid is a specialized nitrogen mustard derivative of toluic acid, serving as a critical advanced intermediate in pharmaceutical research and development. Its molecular structure, featuring a bifunctional alkylating moiety, makes it a valuable precursor for synthesizing targeted therapeutic agents and for use in biochemical studies. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel chemotherapeutic and cytostatic compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nitrogen mustard-based chemotherapeutic agents and prodrugs.
• Biochemical Research: Used as a model alkylating agent in studies of DNA interaction, cytotoxicity, and mechanism of action research.
• Anticancer Drug Development: Serves as a core scaffold for the research and development of potential antitumor compounds.
• Academic & Contract Research: Employed in university and CRO laboratories for medicinal chemistry projects and structure-activity relationship (SAR) studies.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	6-[Bis(2-Chloroethyl)Amino]-m-Toluic Acid
CAS No.	5977-34-4
Molecular Formula	C₁₃H₁₇Cl₂NO₂
Molecular Weight	290.19 g/mol
Synonyms	m-Toluic Acid, 6-[bis(2-chloroethyl)amino]-; 6-[Bis(2-chloroethyl)amino]-3-methylbenzoic Acid; 2-Methyl-5-[N,N-bis(2-chloroethyl)amino]benzoic Acid; 5-[Bis(2-chloroethyl)amino]-2-methylbenzoic Acid; NSC 82174; CB 1851; Chlorambucil Intermediate; Nitrogen Mustard Toluic Acid Derivative
EINECS	Contact for details

Quality Control

Our 6-[Bis(2-Chloroethyl)Amino]-m-Toluic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including identification, purity assay, and impurity profiling to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing the results of tests such as HPLC, NMR, and residual solvent analysis is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.