Description

Hyoscyamine Hydrochloride CAS NO 5934-50-9 is a high-purity, naturally derived tropane alkaloid salt, essential for its potent anticholinergic and antispasmodic properties. This compound is critical for ensuring precise pharmacological activity and batch-to-batch consistency in demanding formulations. It is primarily required by manufacturers in the pharmaceutical, biotechnology, and advanced research sectors for producing antispasmodic medications, ophthalmic solutions, and as a key analytical reference standard.

Application

• Pharmaceutical Active Ingredient (API): Core component in antispasmodic and anticholinergic drug formulations for treating gastrointestinal disorders, irritable bowel syndrome (IBS), and bladder spasms.
• Ophthalmic Solutions: Used in cycloplegic and mydriatic eye drops to dilate the pupil and paralyze accommodation for diagnostic procedures and surgeries.
• Analytical Reference Standard: Serves as a certified primary standard in HPLC, LC-MS, and other chromatographic methods for quality control and research in pharmaceutical labs.
• Precursor for Derivatives: Utilized in the synthesis of more complex pharmaceutical compounds and research chemicals within the tropane alkaloid class.
• Biochemical Research: Employed in pharmacological studies to investigate muscarinic acetylcholine receptor (mAChR) function and signal transduction pathways.
• Veterinary Medicine: Incorporated into formulations for treating colic and spasmodic conditions in animals.

Basic Information

Product Name	Hyoscyamine Hydrochloride
CAS No.	5934-50-9
Molecular Formula	C17H23NO3 · HCl
Molecular Weight	325.83 g/mol
Synonyms	(-)-Hyoscyamine Hydrochloride; Daturine Hydrochloride; Atropine (-)-Isomer Hydrochloride; (S)-(-)-Tropyl Tropate Hydrochloride; Levohyoscyamine Hydrochloride; 3α-Tropanyl (S)-(-)-Tropate Hydrochloride; Belladonnine Hydrochloride (component); Duboisine Hydrochloride
EINECS	227-681-2

Quality Control

Our Hyoscyamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards. Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological tests are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Specific Rotation	-20.5° to -23.5° (c = 5 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.