Description

(2S)-5-Oxo-1,2-Pyrrolidinedicarboxylic Acid 1-Benzyl 2-(2,4,5-Trichlorophenyl) Ester is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (2S) pyrrolidine scaffold into target molecules.
• Peptidomimetic Research: Serves as a precursor for proline analogs and other non-natural amino acid derivatives used in drug design.
• Chemical Biology Probes: Used in the development of enzyme inhibitors and molecular probes for biological target validation.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of chiral compounds.
• Academic Research: A valuable reagent for methodological studies in organic chemistry and catalysis at universities and research institutes.

Basic Information

Product Name	(2S)-5-Oxo-1,2-Pyrrolidinedicarboxylic Acid 1-Benzyl 2-(2,4,5-Trichlorophenyl) Ester
CAS No.	5910-46-3
Molecular Formula	C19H14Cl3NO5
Molecular Weight	450.67 g/mol
Synonyms	1-Benzyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate 2-(2,4,5-Trichlorophenyl) Ester; L-Pyroglutamic Acid 1-Benzyl 2-(2,4,5-Trichlorophenyl) Ester; (S)-1-(Benzyloxycarbonyl)-5-oxopyrrolidine-2-carboxylic Acid 2,4,5-Trichlorophenyl Ester; (2S)-1-[(Benzyloxy)carbonyl]-5-oxo-2-pyrrolidinecarboxylic Acid 2,4,5-Trichlorophenyl Ester; (S)-N-Cbz-pyroglutamic acid 2,4,5-trichlorophenyl ester; N-Cbz-L-pyroglutamic acid 2,4,5-trichlorophenyl ester; N-Cbz-(S)-pyroglutamic acid 2,4,5-trichlorophenyl ester
EINECS	Contact for details

Quality Control

Our production of (2S)-5-Oxo-1,2-Pyrrolidinedicarboxylic Acid 1-Benzyl 2-(2,4,5-Trichlorophenyl) Ester adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.