Description

3-Chloropyridine-2-Thiol is a versatile heterocyclic building block of significant importance in synthetic organic chemistry. Its unique structure, featuring both a chlorine substituent and a thiol group on the pyridine ring, makes it a key intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Used in the development of advanced pesticides, herbicides, and fungicides, leveraging its heterocyclic core for bioactivity.
• Ligand and Catalyst Preparation: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the development of novel polymers, dyes, and functional materials that incorporate sulfur and nitrogen heterocycles.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry and process chemistry for exploring new reaction pathways and molecular libraries.

Basic Information

Product Name	3-Chloropyridine-2-Thiol
CAS No.	5897-94-9
Molecular Formula	C5H4ClNS
Molecular Weight	145.61 g/mol
Synonyms	2-Mercapto-3-chloropyridine; 3-Chloro-2-pyridinethiol; 3-Chloro-2-mercaptopyridine; 2-Pyridinethiol, 3-chloro-; 3-Chloro-2-thiopyridinol; 3-Chloro-2-sulfanylpyridine; 3-Chloro-2-pyridyl mercaptan
EINECS	227-579-4

Quality Control

Our 3-Chloropyridine-2-Thiol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and spectroscopic identification (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for each lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.