Description

D-Leucine Methyl Ester Hydrochloride is a chiral, non-natural amino acid derivative widely used as a critical building block in organic synthesis and pharmaceutical research. Its primary value lies in providing a protected, activated form of D-leucine, enabling precise stereochemical control in the production of peptides, peptidomimetics, and other bioactive compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries developing novel therapeutics and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-leucine residue, which can enhance metabolic stability and alter biological activity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for chiral separation techniques.
• Agrochemical Development: Intermediate in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical Synthesis: Versatile precursor for creating complex organic molecules, flavors, and fragrances requiring specific stereochemistry.
• Protecting Group Strategy: The methyl ester group serves as a common protecting group that can be selectively removed under mild conditions during multi-step syntheses.

Basic Information

Product Name	D-Leucine Methyl Ester Hydrochloride
CAS No.	5845-53-4
Molecular Formula	C7H16ClNO2
Molecular Weight	181.66 g/mol
Synonyms	(R)-2-Amino-4-methylpentanoic acid methyl ester hydrochloride; Methyl (R)-2-amino-4-methylpentanoate hydrochloride; D-2-Aminoisocaproic acid methyl ester HCl; Methyl D-leucinate hydrochloride; (R)-Leucine methyl ester hydrochloride; D-Leu-OMe·HCl; H-D-Leu-OMe·HCl; Methyl (2R)-2-amino-4-methylpentanoate hydrochloride
EINECS	Contact for details

Quality Control

Our D-Leucine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment. We can supply material compliant with various pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.