Description

Methantheline CAS NO 5818-17-7 is a quaternary ammonium anticholinergic agent, recognized for its potent antimuscarinic and ganglionic blocking properties. This compound is of significant interest in pharmaceutical research and development, particularly for its historical and investigative role in modulating autonomic nervous system functions. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical and fine chemical sectors, where precise chemical activity and high purity are paramount.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of specialized anticholinergic agents and related therapeutic molecules.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies to investigate muscarinic acetylcholine receptor (mAChR) antagonism and autonomic nervous system physiology.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control testing of pharmaceutical products.
• Academic Research: Utilized in university and institutional labs for studying the structure-activity relationships (SAR) of quaternary ammonium compounds.
• Fine Chemical Synthesis: Acts as a precursor for the development of novel chemical entities with potential therapeutic applications.

Basic Information

Product Name	Methantheline
CAS No.	5818-17-7
Molecular Formula	C21H26BrNO3
Molecular Weight	420.34 g/mol
Synonyms	Methanthelinium Bromide; Banthine; Methanthelinium; Diethyl(2-hydroxyethyl)methylammonium bromide xanthene-9-carboxylate; 9-Carboxyxanthen-4-yloxyethyldiethylmethylammonium bromide; Xanthene-9-carboxylic acid, 4-[[2-[diethyl(methyl)ammonio]ethoxy]methyl]-, bromide (1:1)
EINECS	227-389-8

Quality Control

Our Methantheline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay (by HPLC), related substances, residual solvents, and appearance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.