Description

n-Acetylmelphalan is a chemically modified derivative of the alkylating agent melphalan, designed to alter its pharmacokinetic profile and stability. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a prodrug or as a key intermediate in synthesizing novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in oncology drug discovery and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the research and synthesis of novel chemotherapeutic agents and targeted cancer therapies.
• Oncology Research: Used in biochemical and pharmacological studies to investigate the mechanisms of alkylating agents and to develop prodrug strategies for improved drug delivery.
• Chemical Synthesis: Acts as a specialized intermediate in organic synthesis for modifying nitrogen mustard compounds and creating analogs with tailored properties.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Bioconjugation Studies: Utilized in research exploring the conjugation of cytotoxic agents to antibodies, polymers, or other targeting moieties.

Basic Information

Product Name	n-Acetylmelphalan
CAS No.	5786-56-1
Molecular Formula	C15H21Cl2N3O3
Molecular Weight	362.25 g/mol
Synonyms	N-Acetyl-L-phenylalanine mustard; N-Acetylmelphalan; N-Acetyl-L-melphalan; L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, N-acetyl-; Acetylmelphalan; NSC 95541; N-Acetyl-4-[bis(2-chloroethyl)amino]-L-phenylalanine
EINECS	Contact for details

Quality Control

Our n-Acetylmelphalan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. The material is light-sensitive and easily oxidized.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.