Description

6α-[[4-[Bis(2-Chloroethyl)Amino]Benzoyl]Amino]Penicillanic Acid is a specialized penicillanic acid derivative that serves as a critical intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the development of targeted therapeutic agents, particularly in oncology research. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of high-potency active pharmaceutical ingredients (HPAPIs) and novel drug conjugates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antibiotic and anticancer agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and new drug discovery programs.
• Antibiotic Derivative Synthesis: Serves as a precursor for developing next-generation β-lactam compounds with modified activity profiles.
• Targeted Drug Conjugates: Employed in the creation of antibody-drug conjugates (ADCs) and other targeted delivery systems due to its functionalizable structure.
• Bioconjugation Chemistry: Utilized in research involving the covalent modification of biomolecules for therapeutic or diagnostic purposes.

Basic Information

Product Name	6α-[[4-[Bis(2-Chloroethyl)Amino]Benzoyl]Amino]Penicillanic Acid
CAS No.	5676-11-9
Molecular Formula	C19H24Cl2N4O4S
Molecular Weight	475.39 g/mol
Synonyms	6-[[[4-[Bis(2-chloroethyl)amino]benzoyl]amino]penicillanic Acid; 6-APA Chlorambucil Derivative; N-(4-Bis(2-chloroethyl)aminobenzoyl)-6-aminopenicillanic Acid; 6-[(4-Bis(2-chloroethyl)aminobenzamido)]penicillanic Acid; Penicillanic Acid, 6-[[[4-[bis(2-chloroethyl)amino]benzoyl]amino]-; 6-ADCA Chlorambucil Amide
EINECS	Contact for details

Quality Control

Our 6α-[[4-[Bis(2-Chloroethyl)Amino]Benzoyl]Amino]Penicillanic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider maintaining the product under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.