Description

n-Succinimidyl Trifluoroacetate is a highly reactive and versatile trifluoroacetylation reagent used for the selective modification of amino groups. Its primary value lies in introducing the trifluoroacetyl (TFA) protecting group, which is exceptionally stable under acidic conditions but can be cleanly removed under mild basic conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, peptide synthesis, and proteomics, where precise control over molecular structure is critical.

Application

• Peptide Synthesis: As a key reagent for the temporary protection of amino groups during solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules requiring selective amine protection.
• Bioconjugation & Labeling: Facilitates the modification of proteins, antibodies, and other biomolecules for analytical, diagnostic, or therapeutic purposes.
• Proteomics Research: Employed in chemical proteomics for labeling and enriching specific classes of proteins or for mass spectrometry sample preparation.
• Material Science: Used to functionalize surfaces and polymers with amine-reactive groups to create advanced materials.
• Organic Synthesis: A valuable building block for introducing the trifluoroacetyl moiety into target molecules in medicinal chemistry.

Basic Information

Product Name	n-Succinimidyl Trifluoroacetate
CAS No.	5672-89-9
Molecular Formula	C6H4F3NO4
Molecular Weight	211.10 g/mol
Synonyms	N-Hydroxysuccinimide Trifluoroacetate; Succinimidyl Trifluoroacetate; Trifluoroacetic Acid N-Hydroxysuccinimide Ester; N-(Trifluoroacetyloxy)succinimide; TFA-OSu; STFA; 2,5-Dioxopyrrolidin-1-yl 2,2,2-trifluoroacetate
EINECS	Contact for details

Quality Control

Our n-Succinimidyl Trifluoroacetate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and synthesis applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.