Description

5'',6'',7'',8''-Tetrahydro-3''H-Spiro[Cyclohexane-1,4''-Quinazoline]-2''-Thiol is a high-value, specialized heterocyclic building block featuring a unique spirocyclic quinazoline-thiol structure. This compound matters for its role as a critical intermediate in the synthesis of complex pharmaceutical agents and advanced organic materials. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its quinazoline-thiol pharmacophore.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the spirocyclic structure can confer unique biological activity and stability.
• Ligand Synthesis: The thiol group makes it a valuable starting material for creating chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the research of advanced organic electronic materials and polymers where the rigid spiro structure can influence material properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5'',6'',7'',8''-Tetrahydro-3''H-Spiro[Cyclohexane-1,4''-Quinazoline]-2''-Thiol
CAS No.	5579-43-1
Molecular Formula	C13H18N2S
Molecular Weight	234.36 g/mol
Synonyms	Spiro[cyclohexane-1,4'-quinazoline]-2'-thiol, 1',2',3',4'-Tetrahydro-; 2-Mercapto-1,2,3,4-tetrahydrospiro[quinazoline-4,1'-cyclohexane]; 2-Thioxo-1,2,3,4-tetrahydrospiro[quinazoline-4,1'-cyclohexane]; Tetrahydrospiro[cyclohexane-1,4'-quinazoline]-2'-thiol; 5579-43-1; Spirocyclic quinazolinethiol; Quinazoline-thiol spirocycle
EINECS	Contact for details

Quality Control

Our 5'',6'',7'',8''-Tetrahydro-3''H-Spiro[Cyclohexane-1,4''-Quinazoline]-2''-Thiol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.