Description

Benzyl n-Benzyloxycarbonyl-Dl-Alaninate is a protected amino acid derivative, specifically the benzyl ester of N-Cbz-DL-alanine. This compound is a crucial building block in peptide synthesis, offering a versatile handle for the orthogonal protection of the alanine carboxylic acid group. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of alanine residues using the benzyl ester protecting group strategy.
• Solution-Phase Peptide Chemistry: Used in classical peptide coupling reactions where selective deprotection of the Cbz and benzyl ester groups is required.
• Pharmaceutical Research: Serves as a critical raw material in the R&D of therapeutic peptides, hormones, and diagnostic agents.
• Bioconjugation: Can be employed in the synthesis of peptide-based linkers for antibody-drug conjugates (ADCs) and other bioconjugates.
• Combinatorial Chemistry: Used in libraries for drug discovery to explore structure-activity relationships (SAR) of peptide sequences.
• Academic Research: A standard reagent in university and institutional labs for teaching and advancing methodologies in organic and bioorganic chemistry.

Basic Information

Product Name	Benzyl n-Benzyloxycarbonyl-Dl-Alaninate
CAS No.	5513-39-3
Molecular Formula	C19H21NO4
Molecular Weight	327.37 g/mol
Synonyms	Benzyl N-Cbz-DL-alaninate; Benzyl (benzyloxycarbonyl)-DL-alaninate; DL-Alanine, N-[(benzyloxy)carbonyl]-, benzyl ester; N-Carbobenzoxy-DL-alanine benzyl ester; Cbz-DL-Ala-OBzl; Z-DL-Ala-OBzl; N-(Benzyloxycarbonyl)-DL-alanine benzyl ester; Alanine, N-carboxy-, N-benzyl ester, benzyl ester, DL-
EINECS	226-848-6

Quality Control

Our Benzyl n-Benzyloxycarbonyl-Dl-Alaninate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	DL-mixture (approx. 50:50)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.