Description

n-(Trifluoroacetyl)-L-Alanine 1-Methylpropyl Ester CAS NO 5513-34-8 is a chiral, fluorinated amino acid derivative used as a critical building block in advanced organic synthesis. Its value lies in the trifluoroacetyl protecting group, which offers unique reactivity and stability profiles compared to standard acetyl groups. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of peptides, enzyme inhibitors, and other bioactive molecules where fluorine substitution is desired to modulate properties like metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide analogs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in research to create inhibitors for enzymes like elastase or other serine proteases.
• Agrochemical Synthesis: Serves as a building block for novel fluorinated pesticides and herbicides, leveraging fluorine's ability to enhance biological activity and environmental persistence.
• Peptide Chemistry: The trifluoroacetyl (Tfa) group acts as an amine-protecting group in solid-phase and solution-phase peptide synthesis, removable under mild conditions.
• Biochemical Research: Utilized in studies of enzyme mechanisms and substrate specificity, where the fluorine atoms serve as probes.
• Material Science: Potential precursor for specialty polymers or coatings with specific surface properties.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Alanine 1-Methylpropyl Ester
CAS No.	5513-34-8
Molecular Formula	C9H14F3NO3
Molecular Weight	241.21 g/mol
Synonyms	L-Alanine, N-(trifluoroacetyl)-, 1-methylpropyl ester; N-Trifluoroacetyl-L-alanine sec-butyl ester; (S)-sec-Butyl 2-(2,2,2-trifluoroacetamido)propanoate; Tfa-L-Ala-O-sec-Bu; 2-(Trifluoroacetamido)propionic Acid sec-Butyl Ester; N-(Trifluoroacetyl)alanine sec-Butyl Ester; Alanine, N-trifluoroacetyl-, sec-butyl ester, L-; 5513-34-8
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Alanine 1-Methylpropyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistent performance. Certificates of Analysis (COA) are provided, detailing parameters such as assay (HPLC), enantiomeric excess, and impurity profiles. We support compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.