Description

2-(8-Methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-(2,3,4-trifluorophenyl)acetamide is a high-purity, complex heterocyclic compound featuring a spirocyclic hydantoin core linked to a trifluorinated aniline moiety. This specific molecular architecture makes it a valuable advanced pharmaceutical intermediate (API) and a critical building block in modern organic synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel active ingredients with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, or anti-infective agents.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, or insecticides, leveraging the biological activity of the hydantoin and fluorinated aryl groups.
• Chemical Biology Probe: Acts as a scaffold or a functionalized ligand in the design of molecular probes for studying enzyme inhibition or receptor binding mechanisms.
• Organic Synthesis Building Block: Employed in medicinal and combinatorial chemistry for constructing complex molecular libraries due to its multifunctional and sterically defined structure.
• Material Science Research: Potential use in the synthesis of specialty polymers or advanced materials where fluorinated and heterocyclic components impart specific physical properties.

Basic Information

Product Name	2-(8-Methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-(2,3,4-trifluorophenyl)acetamide
CAS No.	5457-16-9
Molecular Formula	C17H17F3N3O3
Molecular Weight	368.33 g/mol
Synonyms	2-(8-Methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-(2,3,4-trifluorophenyl)acetamide; 2-(8-Methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-(2,3,4-trifluorophenyl)acetamide; 5457-16-9; Acetamide, 2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-(2,3,4-trifluorophenyl)-; Spiro[4.5]decane-8-methyl-2,4-dioxo-1,3-diazole acetamide derivative; N-(2,3,4-Trifluorophenyl)-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)acetamide
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Quality Control

Our production of 2-(8-Methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-(2,3,4-trifluorophenyl)acetamide adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.