Description

2-Chloro-4'-Hydroxychalcone is a synthetically derived chalcone derivative, a versatile chemical scaffold of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters for its role as a key intermediate in the development of novel bioactive molecules, particularly due to the presence of both chloro and hydroxyl functional groups which allow for targeted chemical modifications. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, as well as by fine chemical manufacturers producing specialized intermediates for agrochemicals and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, particularly for anti-inflammatory, anticancer, and antimicrobial agents.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Organic Synthesis: Acts as a versatile precursor for synthesizing more complex heterocyclic compounds like flavones, aurones, and pyrazolines.
• Biochemical Research: Employed in studies investigating enzyme inhibition, particularly targeting pathways involved in inflammation and cell proliferation.
• Material Science Precursor: Potential use in the development of organic semiconductors or non-linear optical (NLO) materials due to its conjugated π-system.
• Agrochemical Intermediate: Can be utilized in the research and development of new pesticides and herbicides.

Basic Information

Product Name	2-Chloro-4'-Hydroxychalcone
CAS No.	5424-02-2
Molecular Formula	C15H11ClO2
Molecular Weight	258.70 g/mol
Synonyms	(E)-1-(2-Chlorophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 2'-Chloro-4-hydroxychalcone; 3-(4-Hydroxyphenyl)-1-(2-chlorophenyl)-2-propen-1-one; 1-(2-Chlorobenzoyl)-2-(4-hydroxyphenyl)ethylene; Chalcone, 2-chloro-4'-hydroxy-; 2-Chloro-4'-hydroxybenzalacetophenone
EINECS	226-575-5

Quality Control

Our 2-Chloro-4'-Hydroxychalcone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.