Description

Hexa-o-Acetyl-D-Mannitol is a fully acetylated derivative of D-mannitol, a sugar alcohol, characterized by the acetylation of all six hydroxyl groups. This chemical modification significantly enhances its lipophilicity and stability, making it a valuable intermediate for advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, fine chemical, and life science sectors for applications such as chiral synthesis and prodrug development.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Prodrug Development: Serves as a precursor for designing prodrugs, where the acetyl groups can be cleaved enzymatically to release the active parent compound.
• Organic Synthesis: Used as a protected form of D-mannitol in multi-step synthetic routes to control reactivity and stereochemistry.
• Biochemical Research: Employed in glycoscience and carbohydrate chemistry studies to investigate enzyme mechanisms and metabolic pathways.
• Polymer Chemistry: Acts as a multifunctional initiator or monomer in the synthesis of specialized polyesters and other polymeric materials.
• Fine Chemical Production: A critical intermediate for manufacturing high-value specialty chemicals, flavors, and fragrances.

Basic Information

Product Name	Hexa-o-Acetyl-D-Mannitol
CAS No.	5346-76-9
Molecular Formula	C18H26O12
Molecular Weight	434.39 g/mol
Synonyms	D-Mannitol Hexaacetate; 1,2,3,4,5,6-Hexa-O-acetyl-D-mannitol; Hexaacetylmannitol; Mannitol Hexaacetate; D-Mannitol, hexaacetate; Hexa-O-acetylmannitol; Acetylated D-Mannitol; NSC 9235
EINECS	226-304-8

Quality Control

Our Hexa-o-Acetyl-D-Mannitol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Specific Rotation [α]20/D	+23.0° to +25.0° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.