Description

tert-Butylbromoacetate is a versatile and reactive alkylating agent and ester intermediate. Its value lies in its role as a key building block for introducing the tert-butyloxycarbonyl (Boc) protected acetic acid moiety in complex organic syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing complex drug molecules, especially in peptide mimetics and protease inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Peptide Chemistry: Serves as an alkylating agent for the selective modification of amino acid side chains or for introducing protected acetic acid groups.
• Polymer Chemistry: Acts as a monomer or functionalization agent in the synthesis of specialty polymers with tailored properties.
• Organic Synthesis Reagent: Employed in various alkylation, esterification, and C-C bond formation reactions under mild conditions.
• Material Science Research: Used to create novel organic compounds and ligands for catalytic systems.

Basic Information

Product Name	tert-Butylbromoacetate
CAS No.	5292-43-4
Molecular Formula	C6H11BrO2
Molecular Weight	195.06 g/mol
Synonyms	Bromoacetic acid tert-butyl ester; 2-Bromoacetic acid tert-butyl ester; tert-Butyl bromoacetate; t-Butyl bromoacetate; Bromoacetic acid 1,1-dimethylethyl ester; (2-Bromoacetyl)oxy-tert-butane; Acetic acid, bromo-, 1,1-dimethylethyl ester
EINECS	226-124-8

Quality Control

Our tert-Butylbromoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.448 - 1.452
Density (g/mL, 20°C)	1.30 - 1.35

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.