Description

(2R,3S)-2,3-Dihydroxybutanedioic Acid Dimethyl Ester is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. This compound, also known as dimethyl (2R,3S)-tartrate, is valued for its defined stereochemistry, which is crucial for imparting specific optical activity in target molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis, catalysis, and the production of active pharmaceutical ingredients (APIs).

Application

• Chiral Auxiliary and Ligand Synthesis: Used as a precursor for synthesizing chiral ligands and auxiliaries in asymmetric catalysis.
• Pharmaceutical Intermediates: A key starting material in the multi-step synthesis of optically active drugs and complex natural products.
• Agrochemical Production: Employed in the manufacture of enantiomerically pure pesticides and herbicides.
• Fine Chemical Synthesis: Serves as a building block for flavors, fragrances, and other specialty chemicals requiring specific stereochemistry.
• Academic and Industrial Research: Utilized in methodological development and scale-up studies for new synthetic routes.
• Resolution Agent: Can be used in the resolution of racemic mixtures due to its chiral nature.

Basic Information

Product Name	(2R,3S)-2,3-Dihydroxybutanedioic Acid Dimethyl Ester
CAS No.	5057-96-5
Molecular Formula	C6H10O6
Molecular Weight	178.14 g/mol
Synonyms	Dimethyl (2R,3S)-Tartrate; (2R,3S)-Dimethyl Tartrate; (-)-Dimethyl L-Tartrate; L-(-)-Dimethyl Tartrate; Dimethyl L-(-)-Tartrate; (2R,3S)-2,3-Dihydroxysuccinic Acid Dimethyl Ester; Methyl L-tartrate
EINECS	225-743-3

Quality Control

We supply (2R,3S)-2,3-Dihydroxybutanedioic Acid Dimethyl Ester in high-purity grades suitable for demanding synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing parameters such as enantiomeric excess, chemical purity, and specific rotation to guarantee batch-to-batch consistency and performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]20/D	-20.0° to -24.0° (c=1 in H2O)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.