Description

4-Hydroxy Thalidomide is a key pharmaceutical intermediate and active metabolite of thalidomide, offering a critical building block for advanced research and development. This compound is essential for scientists exploring novel immunomodulatory and anti-angiogenic agents, as well as targeted protein degradation technologies like PROTACs. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology, inflammation, and targeted therapeutic discovery.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of thalidomide analogs and next-generation immunomodulatory drugs (IMiDs).
• Biochemical Research: Used as a reference standard and active metabolite in pharmacokinetic and pharmacodynamic studies related to thalidomide.
• PROTAC Development: Acts as a ligand for cereblon (CRBN) E3 ubiquitin ligase in the design and synthesis of Proteolysis Targeting Chimeras (PROTACs).
• Mechanism of Action Studies: Employed to investigate the teratogenic mechanisms and biological pathways modulated by thalidomide derivatives.
• Anti-inflammatory & Anti-cancer Agent Research: Studied for its potential anti-angiogenic, anti-proliferative, and TNF-α inhibitory properties.
• Reference Material: Provides a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	4-Hydroxy Thalidomide
CAS No.	5054-59-1
Molecular Formula	C13H10N2O5
Molecular Weight	274.23 g/mol
Synonyms	4-Hydroxythalidomide; 4'-Hydroxythalidomide; 5-Hydroxythalidomide; Thalidomide 4-OH; Thalidomide, 4-hydroxy-; 2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione; 4-OH-Thal; 5'-Hydroxythalidomide
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Thalidomide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.