Description

3α-(Trimethylsiloxy)-5β-Androstane-11,17-Dione is a high-purity, synthetic steroid derivative featuring a strategically positioned trimethylsilyl (TMS) protecting group. This compound serves as a critical advanced intermediate in the synthesis of complex steroid-based pharmaceuticals and fine chemicals, offering researchers and manufacturers precise control over molecular structure. It is primarily utilized by the pharmaceutical, biotechnology, and advanced organic synthesis sectors for developing novel therapeutic agents and conducting metabolic studies.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) with steroid backbones.
• Research & Development: Used in medicinal chemistry for the design and development of new drug candidates targeting hormone receptors and metabolic pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Biochemical Research: Employed in metabolic studies to investigate steroidogenesis and enzyme inhibition mechanisms.
• Fine Chemical Synthesis: Utilized as a specialized intermediate for creating complex, high-value organic molecules in custom synthesis projects.

Basic Information

Product Name	3α-(Trimethylsiloxy)-5β-Androstane-11,17-Dione
CAS No.	5042-90-0
Molecular Formula	C22H36O3Si
Molecular Weight	376.61 g/mol
Synonyms	3α-(Trimethylsilyloxy)-5β-androstane-11,17-dione; 5β-Androstane-11,17-dione, 3α-(trimethylsilyloxy)-; 3α-Trimethylsiloxy-5β-androstane-11,17-dione; 3-TMS-androstanedione; 11,17-Dioxo-5β-androstan-3α-yl trimethylsilyl ether; Androstane TMS derivative; Steroid TMS ether intermediate
EINECS	Contact for details

Quality Control

Our 3α-(Trimethylsiloxy)-5β-Androstane-11,17-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.