Description

Trimethyl tert-Butyl Silane is a versatile organosilicon compound widely used as a key protecting group reagent and a valuable synthetic intermediate. Its primary value lies in its ability to introduce the bulky, stable tert-butyldimethylsilyl (TBDMS) group, which is crucial for protecting hydroxyl functionalities in complex organic syntheses. This makes it an essential material for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular construction is required.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs), particularly in multi-step sequences requiring selective hydroxyl protection.
• Nucleoside & Carbohydrate Chemistry: Used extensively to protect sugar hydroxyl groups during the synthesis of nucleosides, nucleotides, and complex carbohydrates.
• Agrochemical Synthesis: Serves as a building block and protecting agent in the production of advanced herbicides, fungicides, and plant growth regulators.
• Peptide Synthesis: Employed to protect serine, threonine, and tyrosine side chains during solid-phase and solution-phase peptide synthesis.
• Natural Product Synthesis: A standard reagent for the total synthesis of complex natural products with multiple alcohol functionalities.
• Material Science Precursor: Acts as a starting material or modifying agent in the development of silicone-based polymers and advanced materials.

Basic Information

Product Name	Trimethyl tert-Butyl Silane
CAS No.	5037-65-0
Molecular Formula	C7H18Si
Molecular Weight	130.30 g/mol
Synonyms	tert-Butyldimethylsilane; (1,1-Dimethylethyl)dimethylsilane; TBDMS-H; tert-Butyl(dimethyl)silane; Dimethyl-tert-butylsilane; tert-Butyldimethylsilyl Hydride; 2,2-Dimethylpropyl(dimethyl)silane
EINECS	225-732-1

Quality Control

Our Trimethyl tert-Butyl Silane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.