Description

2-Iodo-1,1-Difluoroethane is a versatile halogenated building block of significant interest in advanced organic synthesis. Its unique structure, featuring both iodine and fluorine atoms, makes it a valuable reagent for introducing difluoroethyl and iodo-difluoroethyl motifs into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the difluoroethyl group can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Fluorination Reagent: Acts as a source of the -CHF2 group in nucleophilic substitution and radical reactions to incorporate fluorine atoms into organic scaffolds.
• Cross-Coupling Substrate: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form carbon-carbon bonds.
• Research & Development: Employed in academic and industrial R&D laboratories for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Iodo-1,1-Difluoroethane
CAS No.	598-39-0
Molecular Formula	C2H3F2I
Molecular Weight	191.95 g/mol
Synonyms	1,1-Difluoro-2-iodoethane; 2-Iodo-1,1-difluoroethane; Iododifluoroethane; Ethane, 2-iodo-1,1-difluoro-; 1,1-Difluoro-2-iodo-ethane; CHF2CH2I; Difluoroiodoethane
EINECS	Contact for details

Quality Control

Our 2-Iodo-1,1-Difluoroethane is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~2.1 g/mL
Boiling Point	~105-110°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.